Zsazsa and her Injection-Site Tumor

A Chihuahua named Zsazsa developed a large injection-site fibrosarcoma after a rabies shot.  Looking for information, Angel Moran (Zsazsa’s  “mom”) e-mailed Kris Christine, Founder of the Rabies Challenge Fund.  Below is Angel’s side of their communication. Kris’s beloved dog Meadow also had a mast cell cancer develop directly on the site of his rabies shot 3 months after it was administered, and he died after it metastasized. The Rabies Challenge Fund is a nonprofit group working to prove that the rabies vaccine gives immunity for at least seven years, thus limiting the number of shots a dog has to get.  The Fund relies exclusively on donations from pet lovers. Please give if you can.

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Angel Moran, writing Sunday, August 30, 2009

Dear Kris: My chihuahua was recently diagnosed with fibrosarcoma. It is at the presumed injection site of her rabies shot. The vet said there is no correlation to her cancer and the injection site but from what I am reading I don’t believe what I am being told. Any studies you have would be greatly appreciated. She developed the lump within 3 months of her booster shot.

Kris sent Angel information from vet journals that we can send you or your vet. 

Other info Kris sent: In a DVM360 article (8-1-08) entitled  Vaccination:  An Overview,  Dr. Melissa Kennedy states: “Adverse reactions have also become a major concern in small animal medicine. …. These fall into two general categories. The first is immediate hypersensitivity. This may be a local or systemic response, and is due to pre-existing antibody to the agent. This is the classic “allergic reaction” to the vaccine and can be life-threatening.  The second is a delayed response, requiring days of longer to develop. The vaccine, seen as foreign, elicits a significant inflammatory response and is especially true for adjuvanted vaccines. This response can manifest as a granuloma, or more seriously, a fibrosarcoma.”  She added: “The likelihood of adverse reactions in dogs has been found to correlate with the size of the dog and the number of inoculations given, with higher risk associated with small size and multiple inoculations.”

Angel writing Monday, October 12, 2009

Kris, I just wanted to give you an update. I had to have my Zsazsa put down this past week. The vet who helped me care for her said the only way to determine 100% her cancer was from the rabies vaccine was to do a biopsy. We agreed to have it done just for our piece of mind and to have her count if this vaccine caused her death. Dr. Amy went to the company who created the vaccine … and she feels the vaccine caused it and explained we have her brother who we are concerned about as well. [The manufacturer] has agreed to pay for the biospy and claim they have no reports of this vaccine causing this cancer in dogs. They are interested in the results. I applaud the Dr for contacting the company and getting them to agree to pay. She warned we couldn’t sue the company but it’s not about that, it’s about the dangers of the rabies vaccine and the numbers not being accurate. Thank you for fighting for our beloved animal’s who can’t fight for themselves.

Angel writing Thursday, October 22, 2009

Dr. Amy called today with the biopsy results for Zsazsa. It was a soft tissue spindle sarcoma and/or with (not sure) peripheral nerve sheath tumor. Dr. Amy thought she had removed the entire tumor but based on the results it was much deeper and she said we made the right decision that Zsazsa would have needed radiation and chemo along with having to have her limb removed. She feels certain it is related to the vaccine and has reported the results to [the manufacturer]. Dr. Amy is going to fax me the results and notes and once I have them I can scan them in and send to you if you would like them. Dr. Amy said they have seen an increase in this type of cancer in dogs and feel it is related to vaccines but they need studies to proof this.

“We found a stray dog and so we have no idea what her vaccination history is or even if she has been spayed. She is probably about a year old at the most…looks like a small yellow lab.

I want to just have her vaccinated for parvo and distemper only and of course we have to have her vaccinated for rabies. But my question for you is how long to wait between the spaying and the vaccinations? And how long between before she gets her rabies shot? And which order do you recommend having all of this done? I know I have seen this information somewhere on the Internet before but it was a long time ago and I just can’t seem to find it now.

I would really appreciate any advice. At this point I don’t even know which thing should be done first, the spaying or the vaccinations.

Note: I got this question from Kat after she watched one of our K9Author YouTube Videos on vaccinating dogs.

Response: Hi Kat.  I’m no fan of the rabies vaccine because of its many adverse reactions. Neither do I like the idea of vaccinating a stressed dog; the vaccine may not “take” and the chance of side effects increases.

However … because most people wouldn’t be comfortable handling a strange dog with no shot history, I’d either have a titer test done to test immunity for rabies (which would prove immunity and not harm the dog, but would cost $150 or so and not allow you to get a license) … or I’d vaccinate.  If you do vaccinate, wait 3 or more weeks before spaying (or neutering) or giving another shot. If you can have a holistic vet or homeopathic vet give the shot, that would be great.  A homeopathic remedy given with the rabies shot can help prevent a reaction.

I would never vaccinate against anything else at the same time as the rabies shot. Instead, I’d have the vet do a titer test for parvovirus and distemper (the two most important diseases) to see if vaccination is even necessary. (This simple blood test should cost $60 – 80 total.) This is the safest route. Because the dog is an adult, she may well be immune to both diseases.

If you decide to vaccinate against parvo and distemper, do NOT do it at the same time as rabies or surgery. And do not vaccinate with a combo shot containing other, probably unnecessary vaccines. Wait 3 weeks or more after rabies or spaying.  Surgery and vaccination are major assaults to the immune system and should be spread out. Specifically tell your vet to never vaccinate during, or within a week or two, of surgery. If your vet does vaccinate without your permission, file a complaint with your local veterinary board. This is a violation of the legal doctrine of informed consent.

As to whether you should spay or vaccinate first, it depends on what you perceive the risks to be: pregnancy or disease. If you can keep the female away from males, go ahead and vaccinate first.

Note: I’m not a vet, but this is what I would do.

Here’s a second question from Kat:

I had actually called a vet earlier today to see how much they charge to titer test for parvo and distemper. At this particular vet’s it was $82.00 plus $43.00 for the office call. I had also called a spay and neuter clinic to see how much they charge to spay and they told me they could give her the vaccinations at the same time. I said, nope! I told them I would not have it done all at one time because I don’t think it’s healthy for the dog. I like your advice of having the rabies shot given first. So I think I will go ahead with that this Saturday then the spay and then the parvo/distemper all spaced 3 weeks apart.

I already ordered her a breakaway dog collar which is also a life saver. Thanks for all of your work in educating people and thus helping dogs to live happier, healthier lives. — Kat

My response:

Kat, you might try having the blood for the titer test tested at hemopet.com. It’s a nonprofit blood bank and testing facility run by renowned vaccine expert Dr. Jean Dodds. Her prices are usually better. Re the blood draw, it should cost no more than $25. It’s just a draw, done by a tech, not an office visit. Try negotiating with your vet … or try another clinic.

Good luck with your new girl and congrats on being such a good guardian to a stranger!

Another question from Kat:

Technorati tags: dog, dogs, vaccination,vaccines, rabies vaccine, shots

Anyway, on to phase two of this whole thing. I am going to be setting up a spay appointment for about 3 1/2 weeks from now. And also I’m going to be searching to find out about the titer testing for parvo and distemper.

Sorry for getting so wordy with this but I just wanted to let you know how we are doing and also to reinforce the fact that people really need to stand their ground about the vaccinations. Because they have innovative ways to try to convince you that your dog needs all of them and right now!

So finally we got up to the veterinarians. I told them we had found her two weeks ago and knew nothing about her history. So one of them asked if I wanted them to scan her for a chip. I said, sure. He said they are supposed to scan in that circumstance anyway. But I had the feeling he wouldn’t have if I had asked him not to. Anyway, he scanned and found nothing and told me I have a dog. I also asked them if they could tell if she’s been spayed.

Rabies-vaccine-induced Ischemic Dermatopathy forced the retirement of Peaches from competition. See the disease on her haunch and ears.

Peaches, Judy Schor’s champion agility dog, retired when she developed Ischemic Dermatopathy after a rabies shot. In March, Judy raised $30,000 with her benefit for the Rabies Challenge Fund, a nonprofit trying to prove that the vaccine gives immunity for at least seven years. Fund researcher Dr. Ron Schultz , and co-Founder Dr. Jean Dodds, spoke about the dangers of the rabies vaccine at the benefit. 

Here is how a shot changed Peaches’s life as told by Judy:
 
As a well intentioned and responsible pet owner, I take my pups in for their annual Well checks and Dental’s. And like clockwork, every 3 years, as required by law, my dogs would get their 3 year Rabies vaccine.
 
In early April of 2007, I took my beloved Rat-Terrier Peaches in for her 7 year Rabies booster. We returned home and nothing unusual noted, however in retrospect, maybe I was remiss in noticing any lethargy or changes as I really never thought that a legally required vaccine could/would cause any harm.
 
So that day, no immediate changes noted, however nearly two months later, in early June 2007, I took Peaches back to the DVM where she had received the Rabies vaccination because she had developed bi-lateral (one on both ears) wedge shaped ear (pinnae) sores.  The doctor dismissed me with an antifungal, antibacterial, antibiotic cream.
 
Peaches competed successfully in Agility through the summer of 2007. She appeared to feel well but the ear lesions remained. During this period, Peaches developed a strange round yellowish skin/fur color change on her right rear haunch. Even the texture of the fur over that area became changed…Silkier feeling, but with a yellowish cast in her otherwise white fur.
 
I had her back again to her regular vet during the summer, but still they could not explain the pinnae sores, neither could they now explain the hair color change…and so we continued competing thru the summer.  I used the cream which seemed to help a little. I began attributing the color change to all of her swimming in the pool, much like blondes whose hair color would change due to the chemicals in swimming pools. Little did I know what journey we were in for.
 
In October of 2007, Peaches entire right rear leg (and gradually her belly) became very edematous (swollen). She was taken to many specialists. Peaches had blood-work, ultrasounds, x-rays, MRI’s, lymph node aspirates, lymph node biopsies, skin biopsies, etc. Then after all this, the DVM’s stated they could find nothing wrong with her. They decided to manage her symptoms with high doses of steroids. My poor little girl, it was heartbreaking to see her suffering from the ill effects of both the drugs and the disease.
 
I spent many late winter nights crying filled with the sadness that I was going to lose my Peach, and the frustration of KNOWING there was something wrong and I had to get to the bottom of it.
 
Then sometime in early February, at one of her Vet visits, I put the symptoms together when one specialty DVM said to me; “When was Peaches last vaccination?”
 
As I got back into the car with Peaches I called the local vet who had given her Rabies booster, and asked that question. I received the name of the vaccine manufacturer, lot number of the vaccine, date it was given, and where it was given..it was given in the right rear haunch where the color change had occurred!
 
That night I went home and began my research on “Google U”, putting in all the symptoms along with the term “vaccination”. My husband, an M.D. was shocked and amazed at the Clinical Studies I pulled up on the net that pointed to exactly the symptoms and disease process that Peaches was experiencing.
 
What I found was a disease written about by well known academic Veterinary DVM’s and labeled “Rabies Vaccine associated Ischemic Dermatopathy”.
 
(I called the vaccine manufacturer and gave them all the details and they asked me to send them all reports which I dutifully did for months until the diagnosis was finally made).
 
My husband and I brought in all the documents from vets across the country on this autoimmune disease caused by the Rabies Vaccine, but our Specialty DVM’s would not label her with this diagnosis. Why? Why? Why wouldn’t they help us? We just wanted to get it diagnosed and treated properly. I heard about the Rabies Challenge Fund and Dr. Jean Dodds. I called her. She got right back to me and she gave me hope and support. Dr. Dodds’ support reinforced us in knowing that I was on the right path and gave me the strength to continue fighting to get a proper diagnosis. And so we continued…
 
We asked the Board Certified Internist and the Board Certified Dermatologist to please make an appointment with Dr. Daniel Morris DVM ACVD at the University of Pennsylvania, as he was one of the authors of one of the many case studies on this autoimmune disease I had pulled up on Google.  We waited 2 weeks without our Specialty DVM calling Dr. Morris. It felt like an eternity with Peaches so sick. I kept calling and asking our Internist to please call and make an appointment for Peaches with Dr. Morris. Nothing.
 
Again, Why? Why was this so hard when we had the clinical studies and documents in our hands that directly pointed to what was wrong with Peaches and the name of the right Doctor to go and see? Why wouldn’t they make the appointment for us? I needed to make Peaches better. I needed someone on my side and that would help her. I was so frustrated and sad.
 
Then sensing where I was at emotionally, enter my husband and hero, Marty Schor, M.D. Marty got on the phone, and less than one week later we were in Dr. Morris’s office at the Matthew J. Ryan Small Animal Hospital at the University of Pennsylvania.
 
We met with Dr. Daniel O. Morris at University of Pennsylvania, and within minutes after checking over Peaches; he at all the months of photo documentation,  at all of the medical reports, studies, biopsies, and said to us, “If it walks like a duck, quacks like a duck, looks like a duck, it’s a duck!”
 
Oh my, how simple! And what a relief to have been finally validated!
 
Peaches “official” diagnosis by Dr. Morris finally occurred in early March of 2008 and by that time had cost us approximately $12K to obtain once we added all the tests and DVM visits up.
 
Finally Peaches was put on the proper meds. She went into complete remission fairly quickly, and was able to compete for 2 trials in October, one year after she became critically ill. I treasured every moment of running with her again. As my friends who are here know, I cried with happiness at the end of each run.
 
Peaches was off all her meds for 3 and a half weeks when symptoms began to reappear with a vengeance.
 
And now she is on meds again and we are trying to keep this awful disease at bay.
 
I am hopeful Peaches will stabilize once again and remain healthy. I treasure every moment with her and her “fur-sisters”!
 
I hope you will, and do, treasure your time with your pet, as you can NEVER believe this will happen to you. [And please donate to the Rabies Challenge Fund.]
  
Very Truly Yours,
 
Judy Schor
     
Peaches’ Career: ADCh Southern Sands Peaches TM-B, JCH-B, *2007 USDAA Regional GP Finalist, AX, AXJ, Clean Run’s Ultimate 60 Weave Pole Breed Champion, CGC    (Retired at 7 yr’s, due to Rabies Vaccine induced Ischemic Dermatopathy ~ Diagnosed by Dr. Daniel O. Morris DVM ACVD Matthew J. Ryan Small Animal Hospital, University of Pennsylvania)

Learn more about rabies vaccine adverse reactions including tips for vaccinating more safely at What You Must Know About the Rabies Vaccine    Also see readers’ rabies vaccination stories (or post your own) my Truth4Dogs.com blog: The Rabies Vaccine and Your Dog: Side Effects

 Technorati tags: dog, dogs, vaccination,vaccines, rabies vaccine, vaccine reactions, adverse reactions, shots

Here is an excerpt from a letter Kris recently sent trying to prevent a change in the law in Muncie, Indiana, from three years to one!  This move is clearly to bring in more revenue with more frequent licensing, as the science in no way supports it.

This letter has valuable information we all should read — especially if you’re living in an area requiring shots more often than the national standard of every three years.

“… recommendations of the American Veterinary Medical Association [1] and the Center for Disease Control’s National Association of State Public Health Veterinarian’s 2008 Compendium of Animal Rabies Prevention and Control advise that: “Vaccines used in state and local rabies control programs should have at least a 3-year duration of immunity…….. No laboratory or epidemiologic data exist to support the annual or biennial administration of 3- or 4-year vaccines following the initial series.”

A regressive ordinance revision requiring annual rabies boosters for dogs and cats is medically unnecessary and scientifically unfounded.  According to the American Animal Hospital Association, “The minimum DOI [duration of immunity] for killed rabies vaccine based on challenge studies is 3 years; based on antibody titers, it is considered to be up to 7 years..” [2] 

More frequent vaccination than is required to fully immunize an animal will not achieve further disease protection.  Redundant annual rabies shots needlessly expose dogs and cats to the risk of adverse effects while obligating residents to pay unnecessary veterinary medical fees, which could violate … consumer protection laws and obligate veterinarians to engage in unprofessional conduct (Code 25-1) by administering medically unwarranted rabies vaccines in order for their clients to comply with the amended ordinance.  The American Veterinary Medical Association’s 2001 Principles of Vaccination state that “Unnecessary stimulation of the immune system does not result in enhanced disease resistance, and may increase the risk of adverse post-vaccination events.”   

It is recognized that most, if not all, currently licensed annual rabies vaccines given annually are actually the 3-year vaccine relabeled for annual use – Colorado State University’s Small Animal Vaccination Protocol for its veterinary teaching hospital states: “Even with rabies vaccines, the label may be misleading in that a three year duration of immunity product may also be labeled and sold as a one year duration of immunity product.”  According to Dr. Ronald Schultz of the University of Wisconsin School of Veterinary Medicine, whose canine vaccine studies form a large part of the scientific base for the 2003 and 2006 American Animal Hospital Association’s (AAHA) Canine Vaccine Guidelines, as well as the World Small Animal Veterinary Association’s 2007 Vaccine Guidelines, “There is no benefit from annual rabies vaccination and most one year rabies products are similar or identical to the 3-year products with regard to duration of immunity and effectiveness.”[3]  

Immunologically, the rabies vaccine is the most potent of the veterinary vaccines and associated with significant adverse reactions such as polyneuropathy “resulting in muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, incoordination, and weakness,” [4] auto-immune hemolytic anemia, [5] autoimmune diseases affecting the thyroid, joints, blood, eyes, skin, kidney, liver, bowel and central nervous system; anaphylactic shock; aggression; seizures; epilepsy; and fibrosarcomas at injection sites are all linked to the rabies vaccine. [6] [7] It is medically unsound for this vaccine to be given more often than is necessary to maintain immunity. 

A “killed” vaccine, the rabies vaccine contains adjuvants to enhance the immunological response.  In 1999, the World Health Organization “classified veterinary vaccine adjuvants as Class III/IV carcinogens with Class IV being the highest risk,” [8] and the results of a study published in the August 2003 Journal of Veterinary Medicine documenting fibrosarcomas at the presumed injection sites of rabies vaccines stated, “In both dogs and cats, the development of necrotizing panniculitis at sites of rabies vaccine administration was first observed by Hendrick & Dunagan (1992).” [9] According to the 2003 AAHA Guidelines, “…killed vaccines are much more likely to cause hypersensitivity reactions (e.g., immune-mediated disease).” [10]

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Learn more about rabies vaccine dangers at our Rabies Vaccine blog or our Rabies Vaccine Information Page.

References:

[1] American Veterinary Medical Association, 2007 RABIES VACCINATION PROCEDURES
[2] American Animal Hospital Association Canine Vaccine Task Force. 2003 Canine Vaccine Guidelines, Recommendations, and Supporting Literature, p.13
[3] Schultz, Ronald D.; What Everyone Needs to Know about Canine Vaccines, October 2007,  
[4]Dodds, W. Jean Vaccination Protocols for Dogs Predisposed to Vaccine Reactions, The Journal of the American Animal Hospital Association, May/June 2001, Vol. 37, pp. 211-214
[5] Duval D., Giger U.Vaccine-Associated Immune-Mediated Hemolytic Anemia in the Dog, Journal of Veterinary Internal Medicine 1996; 10:290-295
[6] American Veterinary Medical Association (AVMA) Executive Board, April 2001, Principles of Vaccination, Journal of the American Veterinary Medical Association, Volume 219, No. 5, September 1, 2001.
[7] Vascelleri, M. Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas; Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291.
[8] IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Volume 74, World Health Organization, International Agency for Research on Cancer, Feb. 23-Mar. 2, 1999, p. 24, 305, 310.
[9] Vascelleri, M. Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas; Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291.
[10] American Animal Hospital Association Canine Vaccine Task Force. 2003 Canine Vaccine Guidelines, Recommendations, and Supporting Literature, 28pp. and ibid. 2006 AAHA Canine Vaccine Guidelines, Revised, 28 pp.

Technorati tags: dog, dogs, vaccination,vaccines, rabies vaccine, vaccine reactions, adverse reactions, shots

Michael Dym, VMD

For the past several decades, the conventional standard of practice has been to give puppies and kittens, as young as three to four weeks of age, multiple viral vaccinations every few weeks until they are about five months old, then repeat the practice very year through their golden years. Years ago, veterinary immunologists and renowned vaccine experts Ron Schultz, DVM and colleague Dr. Phillips wrote in the XI edition of Kirks Current Veterinary Therapy (used in all vet schools), that yearly vaccination for viral diseases is medically unnecessary and is a practice that “lacks scientific validity,” indicating that immunity to most core viral vaccination persists “for years to the life of the animal.”

In 1997, the first International Veterinary Vaccines and Diagnostics Conference concluded that the duration of immunity is likely more than five years for the clinically important companion animal vaccines. Yet, veterinarians continue to routinely over-vaccinate both puppies and adult/senior dogs and cats.

More recently, evidence has emerged that, along with the nutrient-poor processed commercial pet foods, over-vaccinating has been a major factor in the development of the epidemic increases in autoimmune diseases, seizures, hormonal disorders and cancer seen in younger pets. There’s even evidence that genetic changes have occurred due to over-vaccination over many generations. Vaccinating pets with chronic immune mediated illnesses or cancer, or even a history of cancer, is contraindicated, as all vaccine inserts that come with the vaccinations say for “use in healthy animals only.” Studies are now under way to document that even rabies vaccination has immunity that probably lasts from five to 10 years . (Please see the Rabies Challenge Fund and Truth4Dogs.org).

I recommend that animal guardians become better informed about which vaccines are appropriate for their pets and how often or if they should be given or repeated. The health of our canine and feline companions depends upon learning the truth, just as we are now learning the truth about fresh, more nutritional foods.

In practice for 18 years, Dr. Dym developed an interest in holistic and homeopathic veterinary medicine and has studied with Richard Pitcairn, DVM, and PhD, author of Dr. Pitcairn’s Guide to Natural Health for Dogs and Cats. He practices in New Jersey. For additional information, please visit Dr. Michael Dym’s website.

Note from Jan: Find more in-depth articles on vaccination at my Truth4Dogs.com blog.
Vaccinating Unhealthy Pets: Beware Reactions & Vaccine Failure
Vaccinating Dogs: 10 Steps to Eliminating Unnecessary Shots    
Titer Test: Don’t Vaccinate Your Dog Unnecessarily
On my website: Rabies Vaccine Information and Vaccinating Dogs: What Your Vet Won’t Tell You

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