Zsazsa and her Injection-Site Tumor

A Chihuahua named Zsazsa developed a large injection-site fibrosarcoma after a rabies shot.  Looking for information, Angel Moran (Zsazsa’s  “mom”) e-mailed Kris Christine, Founder of the Rabies Challenge Fund.  Below is Angel’s side of their communication. Kris’s beloved dog Meadow also had a mast cell cancer develop directly on the site of his rabies shot 3 months after it was administered, and he died after it metastasized. The Rabies Challenge Fund is a nonprofit group working to prove that the rabies vaccine gives immunity for at least seven years, thus limiting the number of shots a dog has to get.  The Fund relies exclusively on donations from pet lovers. Please give if you can.

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Angel Moran, writing Sunday, August 30, 2009

Dear Kris: My chihuahua was recently diagnosed with fibrosarcoma. It is at the presumed injection site of her rabies shot. The vet said there is no correlation to her cancer and the injection site but from what I am reading I don’t believe what I am being told. Any studies you have would be greatly appreciated. She developed the lump within 3 months of her booster shot.

Kris sent Angel information from vet journals that we can send you or your vet. 

Other info Kris sent: In a DVM360 article (8-1-08) entitled  Vaccination:  An Overview,  Dr. Melissa Kennedy states: “Adverse reactions have also become a major concern in small animal medicine. …. These fall into two general categories. The first is immediate hypersensitivity. This may be a local or systemic response, and is due to pre-existing antibody to the agent. This is the classic “allergic reaction” to the vaccine and can be life-threatening.  The second is a delayed response, requiring days of longer to develop. The vaccine, seen as foreign, elicits a significant inflammatory response and is especially true for adjuvanted vaccines. This response can manifest as a granuloma, or more seriously, a fibrosarcoma.”  She added: “The likelihood of adverse reactions in dogs has been found to correlate with the size of the dog and the number of inoculations given, with higher risk associated with small size and multiple inoculations.”

Angel writing Monday, October 12, 2009

Kris, I just wanted to give you an update. I had to have my Zsazsa put down this past week. The vet who helped me care for her said the only way to determine 100% her cancer was from the rabies vaccine was to do a biopsy. We agreed to have it done just for our piece of mind and to have her count if this vaccine caused her death. Dr. Amy went to the company who created the vaccine … and she feels the vaccine caused it and explained we have her brother who we are concerned about as well. [The manufacturer] has agreed to pay for the biospy and claim they have no reports of this vaccine causing this cancer in dogs. They are interested in the results. I applaud the Dr for contacting the company and getting them to agree to pay. She warned we couldn’t sue the company but it’s not about that, it’s about the dangers of the rabies vaccine and the numbers not being accurate. Thank you for fighting for our beloved animal’s who can’t fight for themselves.

Angel writing Thursday, October 22, 2009

Dr. Amy called today with the biopsy results for Zsazsa. It was a soft tissue spindle sarcoma and/or with (not sure) peripheral nerve sheath tumor. Dr. Amy thought she had removed the entire tumor but based on the results it was much deeper and she said we made the right decision that Zsazsa would have needed radiation and chemo along with having to have her limb removed. She feels certain it is related to the vaccine and has reported the results to [the manufacturer]. Dr. Amy is going to fax me the results and notes and once I have them I can scan them in and send to you if you would like them. Dr. Amy said they have seen an increase in this type of cancer in dogs and feel it is related to vaccines but they need studies to proof this.

Here is an excerpt from a letter Kris recently sent trying to prevent a change in the law in Muncie, Indiana, from three years to one!  This move is clearly to bring in more revenue with more frequent licensing, as the science in no way supports it.

This letter has valuable information we all should read — especially if you’re living in an area requiring shots more often than the national standard of every three years.

“… recommendations of the American Veterinary Medical Association [1] and the Center for Disease Control’s National Association of State Public Health Veterinarian’s 2008 Compendium of Animal Rabies Prevention and Control advise that: “Vaccines used in state and local rabies control programs should have at least a 3-year duration of immunity…….. No laboratory or epidemiologic data exist to support the annual or biennial administration of 3- or 4-year vaccines following the initial series.”

A regressive ordinance revision requiring annual rabies boosters for dogs and cats is medically unnecessary and scientifically unfounded.  According to the American Animal Hospital Association, “The minimum DOI [duration of immunity] for killed rabies vaccine based on challenge studies is 3 years; based on antibody titers, it is considered to be up to 7 years..” [2] 

More frequent vaccination than is required to fully immunize an animal will not achieve further disease protection.  Redundant annual rabies shots needlessly expose dogs and cats to the risk of adverse effects while obligating residents to pay unnecessary veterinary medical fees, which could violate … consumer protection laws and obligate veterinarians to engage in unprofessional conduct (Code 25-1) by administering medically unwarranted rabies vaccines in order for their clients to comply with the amended ordinance.  The American Veterinary Medical Association’s 2001 Principles of Vaccination state that “Unnecessary stimulation of the immune system does not result in enhanced disease resistance, and may increase the risk of adverse post-vaccination events.”   

It is recognized that most, if not all, currently licensed annual rabies vaccines given annually are actually the 3-year vaccine relabeled for annual use – Colorado State University’s Small Animal Vaccination Protocol for its veterinary teaching hospital states: “Even with rabies vaccines, the label may be misleading in that a three year duration of immunity product may also be labeled and sold as a one year duration of immunity product.”  According to Dr. Ronald Schultz of the University of Wisconsin School of Veterinary Medicine, whose canine vaccine studies form a large part of the scientific base for the 2003 and 2006 American Animal Hospital Association’s (AAHA) Canine Vaccine Guidelines, as well as the World Small Animal Veterinary Association’s 2007 Vaccine Guidelines, “There is no benefit from annual rabies vaccination and most one year rabies products are similar or identical to the 3-year products with regard to duration of immunity and effectiveness.”[3]  

Immunologically, the rabies vaccine is the most potent of the veterinary vaccines and associated with significant adverse reactions such as polyneuropathy “resulting in muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, incoordination, and weakness,” [4] auto-immune hemolytic anemia, [5] autoimmune diseases affecting the thyroid, joints, blood, eyes, skin, kidney, liver, bowel and central nervous system; anaphylactic shock; aggression; seizures; epilepsy; and fibrosarcomas at injection sites are all linked to the rabies vaccine. [6] [7] It is medically unsound for this vaccine to be given more often than is necessary to maintain immunity. 

A “killed” vaccine, the rabies vaccine contains adjuvants to enhance the immunological response.  In 1999, the World Health Organization “classified veterinary vaccine adjuvants as Class III/IV carcinogens with Class IV being the highest risk,” [8] and the results of a study published in the August 2003 Journal of Veterinary Medicine documenting fibrosarcomas at the presumed injection sites of rabies vaccines stated, “In both dogs and cats, the development of necrotizing panniculitis at sites of rabies vaccine administration was first observed by Hendrick & Dunagan (1992).” [9] According to the 2003 AAHA Guidelines, “…killed vaccines are much more likely to cause hypersensitivity reactions (e.g., immune-mediated disease).” [10]

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Learn more about rabies vaccine dangers at our Rabies Vaccine blog or our Rabies Vaccine Information Page.

References:

[1] American Veterinary Medical Association, 2007 RABIES VACCINATION PROCEDURES
[2] American Animal Hospital Association Canine Vaccine Task Force. 2003 Canine Vaccine Guidelines, Recommendations, and Supporting Literature, p.13
[3] Schultz, Ronald D.; What Everyone Needs to Know about Canine Vaccines, October 2007,  
[4]Dodds, W. Jean Vaccination Protocols for Dogs Predisposed to Vaccine Reactions, The Journal of the American Animal Hospital Association, May/June 2001, Vol. 37, pp. 211-214
[5] Duval D., Giger U.Vaccine-Associated Immune-Mediated Hemolytic Anemia in the Dog, Journal of Veterinary Internal Medicine 1996; 10:290-295
[6] American Veterinary Medical Association (AVMA) Executive Board, April 2001, Principles of Vaccination, Journal of the American Veterinary Medical Association, Volume 219, No. 5, September 1, 2001.
[7] Vascelleri, M. Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas; Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291.
[8] IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Volume 74, World Health Organization, International Agency for Research on Cancer, Feb. 23-Mar. 2, 1999, p. 24, 305, 310.
[9] Vascelleri, M. Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas; Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291.
[10] American Animal Hospital Association Canine Vaccine Task Force. 2003 Canine Vaccine Guidelines, Recommendations, and Supporting Literature, 28pp. and ibid. 2006 AAHA Canine Vaccine Guidelines, Revised, 28 pp.

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